LATEST NEWS

Search News

2 minutes reading time (377 words)

Clues to Early Detection, Treatment of Alzheimer's

Human brain over molecular map

Brain and blood chemistry changes that indicate Alzheimer's disease can be detected 10 to 20 years before memory loss and other cognitive symptoms develop, according to doctors studying  families with inherited forms of the disease.

Studying people genetically destined to develop Alzheimer's disease at a young age will help researchers understand the changes that occur prior to the development of the "type of Alzheimer's everyone recognizes -- the [non-inherited] form of the disease that  typically strikes people in their 60s, 70s, and 80s," says  John C. Morris, MD, of Washington University in St. Louis.

Morris heads the Dominantly Inherited Alzheimer Network (DIAN), which is recruiting about 400 people whose families harbor genetic mutations that virtually guarantee a person will develop Alzheimer's at the same young age as the parent, usually before age 60.

As part of the NIH-funded program, participants will also be enrolled in clinical trials of potentially disease-modifying drugs that target the underlying processes thought to cause Alzheimer's disease.

The hope is that such drugs will work early on to delay mental decline and slow the progressive degeneration of brain tissue. Currently available drugs like Aricept, Cognex, Exelon, and Razadyne boost mental functioning in a small percentage of people for a time, but none halts the inevitable progression of the disease.

Because study participants are almost certain to develop Alzheimer's disease at a young age, fewer of them need to be followed for a shorter amount of time to show a drug works in the early stages of the disease than if high-risk people in the general population are studied, says DIAN member Randall Bateman, MD, also of Washington University in St. Louis.

The cholesterol-lowering statin drugs that have revolutionized the prevention and treatment of heart disease were first tested in people with an inherited form of high cholesterol, Bateman tells WebMD.

Brain Changes Occur 10 Years Prior to Alzheimer's Symptoms

At the Alzheimer's Association International Conference here, the DIAN researchers presented some early findings gleaned from the first 128 patients to be enrolled in the study:

 

Read more

Ohio serial killer found guilty in kidnappings, mu...
Queen Creek Unified School District seeks board me...
 

Comments

No comments made yet. Be the first to submit a comment
Saturday, 15 June 2024

Captcha Image

My Account Menu

News Menu

Search News

Mailing Address:
530 E Hunt Hwy
Ste 103-262
San Tan Valley, AZ 85143

Text: 602.348.0238

SanTanValley.com is your #1 resource for anything in and around San Tan Valley, AZ. Focusing on uniting and promoting all that San Tan Valley has to offer for our visitors and residents, SanTanValley.com provides you with local area information & events, local business information, news, traffic alerts, and more!

© 2023, SanTanValley.com is owned & operated by MyBizNow LLC. All Rights Reserved. Material displayed is not to be used without written permission by SanTanValley.com representatives. You may not reproduce or communicate any of the content on this website, including articles, content, images and files downloadable from this website, without the written permission of SanTanValley.com representatives. Opinions and comments posted by viewers do not reflect the opinions of SanTanValley.com.

As an Amazon Associate we earn from qualifying purchases.

© Copyright 2023. All Rights Reserved Site Developed & Maintained by MyBizNow.com
× Progressive Web App | Add to Homescreen

To install this Web App in your iPhone/iPad press icon. Progressive Web App | Share Button And then Add to Home Screen.

× Install Web App
Mobile Phone
Offline - No Internet Connection